| RESEARCH ON THE MEDICAL COMPOUND ARTEMISININ AND OPTIMIZATION OF BIOSYNTHESIS TO INCREASE ITS PRODUCTION |
| کد مقاله : 1063-COTTONCRI3 |
| نویسندگان |
|
Bakhtiyor Rakhmanov * Center of Genomics and Bioinformatics
Academy of Sciences the Republic of Uzbekistan |
| چکیده مقاله |
| Artemisinin, a potent antimalarial drug derived from the wormwood plant (Artemisia annua), has revolutionized the treatment of malaria worldwide. Its unique endoperoxide bridges leads to the destruction of malarial parasites. The discovery of artemisinin and its derivatives makes a significant contribution to the fight against drug-resistant malaria by increasing therapeutic efficacy and reducing mortality. In addition to its antimalarial properties, artemisinin exhibits various pharmacological properties including anti-inflammatory, anticancer and immunomodulatory effects, leading to ongoing research on its use in various fields of medicine. Despite its potential, issues such as low bioavailability and the emergence of resistance require continued research and optimization. Artemisinin biosynthesis involves a complex pathway of enzymes and genes. In the plant Artemisia annua, which is the main source of artemisinin, several key genes play critical roles in the biosynthetic pathway. The goal of our research is to increase the synthesis of artemisinin in plant genotypes by optimizing these enzymes and regulating their expression levels through the application of cutting-edge molecular biology and genetic engineering techniques. |
| کلیدواژه ها |
| Artemisinin, medicinal compound, yield improvement |
| وضعیت: پذیرفته شده برای ارائه شفاهی |
